When the Prophet used to go to meditate in the cave of Hira on Jabel-e-Noor, it was Hadrat Khadija (SA) herself who would climb up there to give him his food and necessaries. She was the first person to accept Islam as taught by the Prophet (pbuh&hf).
In 616 AD, the Quraish isolated the Bani Hashim (the family of the Prophet) and they took refuge in a ravine called Shib-e-Abu Talib. Hadrat Khadija (SA) was there too and it was her wealth (which she donated for Islam) that sustained the Muslims at that time. The siege lasted for 3 years during which time they experienced hunger, thirst, and the cold and heat of the desert.